MIP1 antibody (70R-12306)
Rabbit polyclonal MIP1 antibody
Overview
Overview
| Synonyms | Polyclonal MIP1 antibody, anti-MIP1 antibody, MIP-1, MIP-1 antibody, macrophge inhibitory protein-1 beta antibody, MIP 1 beta antibody, MIP1, macrophge inhibitory protein antibody, MIP 1 antibody, macrophge inhibitory protein 1 beta antibody, MIP 1 antibody, MIP-1 antibody, MIP 1b antibody, MIP-1b antibody, MIP 1 |
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| Cross Reactivity | Mouse, Rat |
| Applications | IP, Neutralization, WB |
| Immunogen | MIP1 antibody was raised in Rabbit using E coli-expressed recombinant mature rat MIP-1beta (aa 1-69) as the immunogen. |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | MIP1 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in PBS buffer, pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Usage Recommendations | IP: 4-8 ug/ml, WB: 0.5-1 ug/ml |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and Mouse MIP-1 alpha and MIP-1 beta are active on human and Mouse hematopoietic cells. |
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