MIP1 protein (80R-4323)
Purified Recombinant MIP1 protein (His tagged)
Overview
Overview
| Synonyms | Timp1 protein, Timp protein, TIMP-1 protein |
|---|---|
| Species | Rat |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS-PAGE analysis using MIP1 protein (His tag) (80R-4323)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 24-217 aa: CSCAPTHPQT AFCNSDLVIR AKFMGSPEII ETTLYQRYEI KMTKMLKGFD AVGNATGFRF AYTPAMESLC GYVHKSQNRS EEFLIAGRLR NGNLHITACS FLVPWHNLSP AQQKAFVKTY SAGCGVCTVF PCSAIPCKLE SDSHCLWTDQ ILMGSEKGYQ SDHFACLPRN PDLCTWQYLG VSMTRSLPLA KAEAHHHHHH |
|---|---|
| Expression System | Insect cells |
| Grade & Purity | > 90% pure |
| Molecular Weight | 22.3 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in PBS buffer (pH 7.4) containing 10% glycerol |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage, aliquot and store at -20 or -70 deg C. Avoid repeat freeze/thaw cycles |
|---|---|
| Endotoxin Levels | < 1.0 EU per 1 microgram of protein |
General Information
| Biological Significance | TIMP1, also known as metalloproteinase inhibitor 1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. MMP1 functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. It plays a role in integrin signaling. Recombinant rat TIMP1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
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