Mouse anti Human IgG Lambda (40R-1014)
Mouse anti Human IgG Lambda Light Chain secondary antibody
Overview
Overview
| Synonyms | Monoclonal IgG lambda antibody, Anti-IgG lambda antibody, Immunoglobulin G lambda locus antibody, Immunoglobulin G lambda antibody, IgG Lambda Light Chain antibody |
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| Specificity | Human Ig Lambda Light Chain |
| Applications | ELISA |
| Immunogen | Mouse anti Human IgG Lambda antibody was raised in Mouse using purified human IgG Lambda Light Chain as the immunogen. |
Specifications
| Host | Mouse |
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| Isotype | IgG2a |
| Method of Purification | Mouse anti Human IgG Lambda antibody was purified by Ion exchange chromatography |
| Form & Buffer | Supplied in lyophilized form, reconstitute in sterile H2O or PBS buffer |
Usage & Assay Information
| Usage Recommendations | ELISA: 1:10,000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. |
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