Mouse MASP2 protein (30R-3406)
Recombinant Mouse MASP2 protein
Overview
Overview
| Synonyms | Recombinant MASP2 protein, MASP2 antigen, Murine MASP2, Mannan Binding Lectin Serine Peptidase 2 protein, Mannan-Binding Lectin Serine Peptidase 1 Pseudogene 1 protein, Mannan-Binding Lectin Serine Protease 1 Pseudogene 1 protein, Mannose-Binding Protein-Associated Serine Protease 2 protein, Mannan-Binding Lectin Serine Peptidase 2 protein, MBL-Associated Serine Protease 2 protein, MASP-2 protein, MASP 2 protein, Mannan-Binding Lectin Serine Protease 2 protein, MBL-Associated Plasma Protein Of 19 KD, Small MBL-Associated Protein, EC 3.4.21.104 protein, EC 3.4.21 protein, MASP1P1 protein, MAP19 protein, SMAP protein |
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| Species | Mouse |
| Protein Type | Recombinant |
Specifications
| Residues | Amino acids 20-685 with N-terminal His tag: S KWPEPVFGRL VSPGFPEKYA DHQDRSWTLT APPGYRLRLY FTHFDLELSY RCEYDFVKLS SGTKVLATLC GQESTDTEQA PGNDTFYSLG PSLKVTFHSD YSNEKPFTGF EAFYAAEDVD ECRVSLGDSV PCDHYCHNYL GGYYCSCRAG YVLHQNKHTC SALCSGQVFT GRSGYLSSPE YPQPYPKLSS CTYSIRLEDG FSVILDFVES FDVETHPEAQ CPYDSLKIQT DKGEHGPFCG KTLPPRIETD SHKVTITFAT DESGNHTGWK IHYTSTARPC PDPTAPPNGS ISPVQAIYVL KDRFSVFCKT GFELLQGSVP LKSFTAVCQK DGSWDRPMPE CSIIDCGPPD DLPNGHVDYI TGPEVTTYKA VIQYSCEETF YTMSSNGKYV CEADGFWTSS KGEKLPPVCE PVCGLSTHTI GGRIVGGQPA KPGDFPWQVL LLGQTTAAAG ALIHDNWVLT AAHAVYEKRM AASSLNIRMG ILKRLSPHYT QAWPEEIFIH EGYTHGAGFD NDIALIKLKN KVTINGSIMP VCLPRKEAAS LMRTDFTGTV AGWGLTQKGL LARNLMFVDI PIADHQKCTA VYEKLYPGVR VSANMLCAGL ETGGKDSCRG DSGGALVFLD NETQRWFVGG IVSWGSINCG AADQYGVYTK VINYIPWIEN IISNF |
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| Expression System | Yeast |
| Grade & Purity | > 90% pure |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as a liquid in a Tris-based buffer with 50% glycerol |
Storage & Safety
| Storage | Store at -20 or -70 deg C in small aliquots. |
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General Information
| Biological Significance | The masp2gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. |
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| Expression | Expressed in plasma |
| Implications in Disease | Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the MASP2 protein. |
| Database Links | Uniprot No. Q91WP0 |
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