Mouse MASP2 protein (30R-3407)

Recombinant Mouse MASP2 protein

Synonyms Recombinant MASP2 protein, MASP2 antigen, Murine MASP2, MBL-Associated Serine Protease 2 protein, MASP-2 protein, MASP 2 protein, EC 3.4.21.104 protein, EC 3.4.21 protein, MASP1P1 protein, MAP19 protein, SMAP protein, Mannan Binding Lectin Serine Peptidase 2 protein, Mannan-Binding Lectin Serine Protease 1 Pseudogene 1 protein, Mannose-Binding Protein-Associated Serine Protease 2 protein, Mannan-Binding Lectin Serine Peptidase 2 protein, Mannan-Binding Lectin Serine Peptidase 1 Pseudogene 1 protein, Mannan-Binding Lectin Serine Protease 2 protein, MBL-Associated Plasma Protein Of 19 KD, Small MBL-Associated Protein
Species Mouse
Protein Type Recombinant

Specifications

Residues Amino acids 20-685 with N-terminal His tag: S KWPEPVFGRL VSPGFPEKYA DHQDRSWTLT APPGYRLRLY FTHFDLELSY RCEYDFVKLS SGTKVLATLC GQESTDTEQA PGNDTFYSLG PSLKVTFHSD YSNEKPFTGF EAFYAAEDVD ECRVSLGDSV PCDHYCHNYL GGYYCSCRAG YVLHQNKHTC SALCSGQVFT GRSGYLSSPE YPQPYPKLSS CTYSIRLEDG FSVILDFVES FDVETHPEAQ CPYDSLKIQT DKGEHGPFCG KTLPPRIETD SHKVTITFAT DESGNHTGWK IHYTSTARPC PDPTAPPNGS ISPVQAIYVL KDRFSVFCKT GFELLQGSVP LKSFTAVCQK DGSWDRPMPE CSIIDCGPPD DLPNGHVDYI TGPEVTTYKA VIQYSCEETF YTMSSNGKYV CEADGFWTSS KGEKLPPVCE PVCGLSTHTI GGRIVGGQPA KPGDFPWQVL LLGQTTAAAG ALIHDNWVLT AAHAVYEKRM AASSLNIRMG ILKRLSPHYT QAWPEEIFIH EGYTHGAGFD NDIALIKLKN KVTINGSIMP VCLPRKEAAS LMRTDFTGTV AGWGLTQKGL LARNLMFVDI PIADHQKCTA VYEKLYPGVR VSANMLCAGL ETGGKDSCRG DSGGALVFLD NETQRWFVGG IVSWGSINCG AADQYGVYTK VINYIPWIEN IISNF
Expression System E.coli
Grade & Purity > 90% pure
Tag/Conjugate His tag
Form & Buffer Supplied as a liquid in a Tris-based buffer with 50% glycerol

Storage & Safety

Storage Store at -20 or -70 deg C in small aliquots.

General Information

Biological Significance Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP2) is an enzyme that in humans is encoded by the MASP2 gene. MASP2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognizing heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.
Expression Expressed in plasma
Implications in Disease Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the MASP2 protein.
Database Links Uniprot No. Q91WP1

References
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Availability: In stock

Price: €1,649.08
Size: 1 mg
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