MPL antibody (70R-51960)

Purified rabbit polyclonal MPL antibody

Synonyms MPL antibody, TPOR antibody, MPLV antibody, CD110 antibody, TPO-R antibody, C-MPL antibody, C-mpl antibody, myeloproliferative leukemia virus antibody, Thrombopoietin antibody, TPO receptor antibody
Specificity Glycosylated and unglycosylated TPO receptor/c-Mpl
Applications IHC, IP, WB
Immunogen KLH-conjugated, synthetic peptide corresponding to amino acids 615-628 of human TPO (thrombopoietin) receptor (C-ANHSYLPLSYWQQP)

Specifications

Host Rabbit
Isotype IgG
Method of Purification Protein A chromatography
Form & Buffer Supplied as liquid in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Storage & Safety

Storage Store at -20 deg C in small aliquots

General Information

Biological Significance V-MPL, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation.
Implications in Disease TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: €584.05
Size: 200 ug
OR
Shipping
View Our Distributors