This antibody recognizes an internal epitope of MRP1
Applications
FC, IHC-F, IHC-P
Immunogen
MRP1 antibody was raised in mouse using fusion protein containing the C-terminus with part of the carboxy-proximal nucleotide-binding domain of MRP1 protein as the immunogen.
Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
General Information
Biological Significance
MRP1 (also known as ABCC, GS-X, ABC29) functions as a multispecific organic anion transporter, with (oxidized) glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. It also transports drugs and other hydrophobic compounds in presence of glutathione. Mab MRPm6 reacts with an internal epitope of MRP1 (aa 1511 – 1520), a 1531 aa protein, overexpressed in various human non-Pglycoprotein MDR tumor cell lines. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human cMOAT / MRP2 to MRP5.