MTPN protein (His tag) (80R-1383)
Purified recombinant Human MTPN protein
|Synonyms||Protein V1 protein, Protein V 1 protein, Protein V-1 protein, , Myotrophin protein, GCDP protein|
Coomassie Blue stained SDS-PAGE of MTPN protein (His tag) (80R-1383)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-118 amino acids: MGSSHHHHHH SSGLVPRGSH MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPDGLTAFEATDN QAIKALLQ|
|Grade & Purity||> 90% pure|
|Molecular Weight||15.0 kDa(138aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||MTPN (myotrophin), an ankyrin repeat protein, stimulates protein synthesis and cardiomyocyte growth to initiate cardiac hypertrophy by activating the NF-kappaB signaling cascade. This protein plays a potential role in cerebellar morphogenesis and may function in differentiation of cerebellar neurons, particularly of granule cells. Elevated levels of MTPN are expressed in human dilated cardiomyopathic and ischemic hearts. Recombinant human MTPN, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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