MUC1 antibody (10R-M129a)

Mouse monoclonal MUC1 antibody

Synonyms Monoclonal MUC1 antibody, Anti-MUC1 antibody, Mucin-1 antibody, MU-1c antibody, MUC1, MU-1c, MU 1c, MU 1c antibody, MU-1c antibody, MU 1c antibody
Specificity Human
Cross Reactivity To be determined by end-user
Applications IHC-F, IHC-P
Immunogen MUC1 antibody was raised in mouse using human milk fat globule membranes as the immunogen.

Images

Immunohistochemical staining using MUC1 antibody (10R-M129a)

Formalin-fixed, paraffin-embedded human breast carcinoma stained with MUC1 antibody using peroxidase-conjugate and AEC chromogen. Note membrane staining of tumor cells.

Specifications

Host Mouse
Clone GP1.4
Isotype IgG1
Method of Purification MUC1 antibody was purified by Protein G chromatography.
Molecular Weight 265-400 kDa (predicted detection band MW)
Form & Buffer 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.
Concentration 0.2 mg/ml

Usage & Assay Information

Usage Recommendations IHC-F: 0.1-0.2 ug/ml, IHC-P: 0.1-0.2 ug/ml

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost.

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Images

  • Immunohistochemical staining using MUC1 antibody (10R-M129a) | Formalin-fixed, paraffin-embedded human breast carcinoma stained with MUC1 antibody using peroxidase-conjugate and AEC chromogen. Note membrane staining of tumor cells.

Availability: In stock

Price: €399.86
Size: 200 ug
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