MUC1 antibody (10R-M129b)
Hamster monoclonal MUC1 antibody
Overview
Overview
| Synonyms | Monoclonal MUC1 antibody, Anti-MUC1 antibody, MU 1c, MU-1c antibody, MU-1c, Mucin-1 antibody, MU-1c antibody, MU 1c antibody, MU 1c antibody, MUC1 |
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| Cross Reactivity | Human, mouse |
| Applications | FC, IF, IHC, IP, WB |
| Immunogen | MUC1 antibody was raised in hamster using a synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1 as the immunogen. |
Images
Immunohistochemical staining using MUC1 antibody (10R-M129b)
Formalin-fixed, paraffin-embedded human breast cancer stained with MUC1 antibody using alkaline phosphatase-conjugate and fast red chromogen. Note nuclear and cytoplasmic staining of tumor cells.
Specifications
| Host | Hamster |
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| Clone | MH1 |
| Isotype | IgG |
| Method of Purification | MUC1 antibody was purified by Protein G chromatography. |
| Form & Buffer | 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3. |
| Concentration | Batch dependent - please inquire should you have specific requirements |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by end user |
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Storage & Safety
| Storage | Store at 4 deg C. |
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| Biohazard Information | This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
General Information
| Biological Significance | Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. |
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