Myostatin protein (30R-AM035)

Purified recombinant Human Myostatin protein

Synonyms GDF-8 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Myostatin beta protein corresponding to amino acids DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 25 kDa
Form & Buffer Lyophilized with no additives. Reconstitute with water to 0.1 - 1.0 mg/ml . Due to the solubility reasons the protein should be kept at low pH.

Usage & Assay Information

Bioactivity Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Contaminants Supplied lyophilized with no additives.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Myostatin is a TGF beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin.

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Availability: In stock

Price: €211.69
Size: 10 ug
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