NET1 antibody (70R-10628)

Affinity purified Chicken polyclonal NET1 antibody

Synonyms Polyclonal NET1 antibody, Anti-NET1 antibody, NET1, Neuroepithelial Cell Transforming Gene 1 antibody, NET-1 antibody, NET 1, NET-1, NET 1 antibody, ARHGEF8 antibody, NET1A antibody
Applications User optimized
Immunogen NET1 antibody was raised in Chicken using a synthetic peptide (Human O_095631 and Mouse O_09118) / keyhole limpet hemocyanin (KLH) conjugate corresponding to different regions of the NET1 gene product as the immunogen.

Images

Immunofluorescent staining of Netrin 1 antibody (70R-10628)

Dissociated cell cultures of an e13 mouse brain showing Netrin-1 (green staining) in neuronal precursor cells.

Specifications

Host Chicken
Method of Purification NET1 antibody was purified by affinity chromatography.
Form & Buffer Supplied in liquid form in 10 mM PBS buffer, pH 7.2, with 0.02% sodium azide added as a preservative.
Concentration 100 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. Protect from light.

General Information

Biological Significance Netrins are a class of proteins involved in axon guidance. Netrins are genetically conserved across nematode worms[2], fruitflies, frogs, and mice. Structurally, netrin resembles laminin. Chemoattraction is mediated through netrin-1 binding with the DCC receptor. Chemrepulsion is mediated by the DCC/UNC-5 association. Netrins are chemotropic, a growing axon will either move towards or away from a higher concentration of netrin. Though the detailed mechanism of axon guidance is not fully understood, it is known that netrin attraction is mediated through UNC-40/DCC cell surface receptors and repulsion is mediated through UNC-5 receptors. Netrins also act as growth factors.

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Images

  • Immunofluorescent staining of Netrin 1 antibody (70R-10628) | Dissociated cell cultures of an e13 mouse brain showing Netrin-1 (green staining) in neuronal precursor cells.

Availability: In stock

Price: €502.25
Size: 1 ml
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