Neuropoietin protein (Mouse) (30R-AN046)

Purified recombinant Mouse Neuropoietin protein

Synonyms NPO protein, NP protein
Species Mouse
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Neuropoietin protein corresponding to amino acids MAPISPSEPI GQAYSLALYM QKNTSALLQT YLQHQGSPFS DPGFSAPELQ LSTLPSAAVS FKTWHAMEDA ERLSRAQGAF LALTQHLQLV GDDQSYLNPG SPILLAQLGA ARLRAQGLLG NMAAIMTALG LPIPPEEDTL GFVPFGASAF ERKCRGYIVT REYGHWTDRA VRDLALLKAK YSA.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 19.8 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 ug/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Neuropoietin is a newly identified member of the IL6 cytokine family. Members of this family, including IL6, IL11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF2.

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Availability: In stock

Price: €211.69
Size: 25 ug
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