NKRP1A antibody (10-2556)
Rat monoclonal NKRP1A antibody
Overview
Overview
| Synonyms | Monoclonal NKRP1A antibody, Anti-NKRP1A antibody, CD161, CLEC5B, hNKR-P1A, killer cell lectin-like receptor subfamily B member 1, killer cell lectin-like receptor subfamily B, member 1, KLRB1, MGC138614, NKR, NKR-P1, NKR-P1A, NKRP1A, Q12918 antibody |
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| Specificity | Rat |
| Cross Reactivity | Mouse |
| Applications | FC |
| Immunogen | NKRP1A antibody was raised in Rat using YB2/0 rat plasmacytoma cells transfected with NKRP1 as the immunogen |
Specifications
| Host | Rat |
|---|---|
| Clone | 3B3 |
| Isotype | IgG2a |
| Method of Purification | NKRP1A antibody purified by affinity chromatography |
| Form & Buffer | Supplied as liquid in PBS with 0.02% sodium azide |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store as concentrated solution. Aliquot and store at -20 deg C or below. Avoid repeated freeze-thaw cycles. |
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General Information
| Biological Significance | NKRP1A plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. |
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