NP1 protein (30R-AN044)

Purified recombinant Human NP1 protein

Synonyms NP 1 protein, NP 1, Cryptdin protein, alpha Defensin-1 protein, Neutrophil Peptide-1 protein, HNP-1 protein, NP1, NP-1, NP-1 protein, NP-1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of NP1 protein corresponding to amino acids ACYCRIPACI AGERRYGYCI YQGRLWAFCC.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 3.4 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins which include NP-1, NP-2 and NP-3, are distinguished from the beta-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds.

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Availability: In stock

Price: €211.69
Size: 20 ug
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