NQO1 protein (His tag) (80R-1197)
Purified recombinant Human NQO1 protein
|Synonyms||NQO 1 protein, DTD protein, DIA 4 protein, NAD(P)H:quinone oxireductase protein, NMOR 1 protein, NQO 1, NAD(P)H:menadione oxidoreductase 1 protein, DT-diaphorase protein, QR 1 protein, DHQU protein, quinone 1 protein, NAD(P)H:Quinone acceptor oxidoreductase type 1 protein, NAD(P)H dehydrogenase quinone 1 NAD(P)H menadione oxidoreductase 1 dioxin inducible protein, NMOR1 protein, NAD(P)H dehydrogenase protein, NQO 1 protein, NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1 protein, DT diaphorase protein, Phylloquinone reductase protein, Diaphorase 4 Dioxin inducible 1 protein, QR1 protein, Azoreductase protein, NMOR I., Diaphorase (NADH/NADPH) (cytochrome b 5 reductase) protein, NQO1, Azoreductase.Menadione reductase protein, Quinone reductase 1 protein, DIA4 protein, NAD(P)H:quinone oxidoreductase 1 protein, Cytochrome b 5 reductase protein, NMORI protein, NQO-1, Diaphorase (NADH/NADPH) protein, NQO-1 protein|
Coomassie Blue stained SDS-PAGE of NQO1 protein (His tag) (80R-1197)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-274 amino acids: Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV FIGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK|
|Grade & Purity||> 95% pure|
|Molecular Weight||33.0 kDa (294aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCL buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This protein apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. NQO1 functions as an important part of cellular antioxidant defense by detoxifying quinines thus preventing the formation of reactive oxygen species. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer’s disease (AD). Recombinant NQO1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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