NSMCE2 antibody (70R-3196)

Rabbit polyclonal NSMCE2 antibody

Synonyms Polyclonal NSMCE2 antibody, Anti-NSMCE2 antibody, MMS21 antibody, NSE2 antibody, Non-Smc Element 2 Mms21 Homolog antibody, NSMCE 2, NSMCE-2, NSMCE2, C8orf36 antibody, NSMCE 2 antibody, FLJ32440 antibody, NSMCE-2 antibody
Cross Reactivity Human
Applications WB
Immunogen NSMCE2 antibody was raised using a synthetic peptide corresponding to a region with amino acids KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE
Assay Information NSMCE2 Blocking Peptide, catalog no. 33R-4372, is also available for use as a blocking control in assays to test for specificity of this NSMCE2 antibody

Images

Western Blot analysis using NSMCE2 antibody (70R-3196)

NSMCE2 antibody (70R-3196) used at 1 ug/ml to detect target protein.

Specifications

Host Rabbit
Method of Purification Affinity purified
Molecular Weight 28 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 50ul distilled water for a 1mg/ml concentration of NSMCE2 antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

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Images

  • Western Blot analysis using NSMCE2 antibody (70R-3196) | NSMCE2 antibody (70R-3196) used at 1 ug/ml to detect target protein.

Availability: In stock

Price: €324.59
Size: 50 ug
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