NTAL protein (His tag) (80R-1325)
Purified recombinant Human NTAL protein
|Synonyms||LAB protein, HSPC046 protein, Non-T-cell activation linker LAB protein, Williams Beuren syndrome chromosome region 5, Wbscr15 protein, Membrane associated adapter molecule protein, LAT2 protein, WBSCR5 protein, Linker for activation of T cells family member 2 protein, WSCR5 protein, WBSCR15 protein, Lat2 protein, Linker for activation of B cells protein, Williams Beuren syndrome chromosome region 15 protein, Non T cell activation linker protein, WBSCR 5 protein|
Coomassie Blue stained SDS-PAGE of NTAL protein (His tag) (80R-1325)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||27-243 amino acids: MGSSHHHHHH SSGLVPRGSH MRCSRPGAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE EDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA|
|Grade & Purity||> 80% pure|
|Molecular Weight||26.2 kDa (238aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl Buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||NTAL (non-T cell activation linker), as known as LAT2, is transmembrane adaptor protein (TRAP) associated with glycolipid-enriched membrane fractions (GEM or lipid rafts). This protein is primarily expressed in spleen and hematopoietic cells, such as B cells, mast cells, NK cells, and monocytes, but not resting T cells. Defects in NTAL may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS). Recombinant human NTAL, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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