Osteoprotegerin protein (30R-AO001)

Purified recombinant Human Osteoprotegerin protein

Synonyms osteoclastogenesis inhibitory factor protein, TNFRSF11B protein, OCIF protein, OPG protein, TR1 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Osteoprotegerin protein corresponding to amino acids METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 20.0 kDa
Form & Buffer Lyophilized from 10mM tris, pH 7.5, with 75mM NaCl. Reconstitute with 5mM Tris pH 7.5 to 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of soluble RANKL (sRANKL).

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG.

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Availability: In stock

Price: €277.55
Size: 50 ug
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