OX40 Ligand protein (30R-AO007)
Purified recombinant Human OX40 Ligand protein
Overview
Overview
| Synonyms | OX40 Ligand, OX40L protein, OX Ligand-40, CD252 protein, OX Ligand-40 protein, OX Ligand 40 protein, Gp34 protein, TNFSF4 protein, OX Ligand 40 |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Expression System | Hi-5 cells |
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| Grade & Purity | > 97% pure |
| Molecular Weight | 15.5-25 kDa |
| Form & Buffer | Supplied as a lyophilized powder. |
Usage & Assay Information
| Bioactivity | Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL2, IL3, and IFN. |
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