p53 antibody (Phospho-Ser6) (20R-2982)
Rabbit polyclonal p53 antibody (Phospho-Ser6)
Overview
Overview
| Synonyms | Polyclonal p53 antibody, Anti-p53 antibody, TP53 antibody, tumor protein p53 antibody, antigen NY-CO-13 antibody, BCC7 antibody, BOS_18908 antibody, brp53 antibody, cellular tumor antigen p53 antibody, drp53 antibody, EGK_08142 antibody, etID22686.5 antibody, fb40d06 antibody, LFS1 antibody, Li-Fraumeni syndrome antibody, p53 antibody, p53 tumor suppressor antibody, p53 tumor suppressor phosphoprotein antibody, phosphoprotein p53 antibody, transformation related protein 53 antibody, transformation-related protein 53 antibody, trp53 antibody, tumor protein 53 antibody, tumor protein p53 (Li-Fraumeni syndrome) antibody, tumor suppressing protein antibody, tumor suppressor homolog p53 antibody, Tumor suppressor p53 antibody, tumor suppressor protein antibody, tumor suppressor protein p53 antibody, tumor suppressor TP53 antibody, tumor supressor p53 antibody, Xp53 antibody |
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| Cross Reactivity | Human |
| Applications | WB |
| Immunogen | p53 antibody was raised in Rabbit using Synthetic phospho-peptide as the immunogen |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | p53 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:1000 |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | p53 is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. p53 has been described as "the guardian of the genome", referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms: activating DNA repair proteins when DNA has sustained damage, holding the cell cycle at the G1/S regulation point on DNA damage recognition, initiating apoptosis if the DNA damage proves to be irrepairable. Human p53 is 393 amino acids long and has three domains: N-terminal transcription-activation domain (TAD), which activates transcription factors. 2) central DNA-binding core domain (DBD) 3) C-terminal homo-oligomerisation domain (OD); tetramerization greatly increases the activity of p53 in vivo. |
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