p57 antibody (10R-11457)

Mouse monoclonal p57 antibody

Synonyms p57 Kip2 antibody, p57 antibody, Kip2 antibody, Cyclin-dependent kinase inhibitor 1C antibody, CDKN1C antibody, p57/Kip2 antibody
Specificity Human p57 protein
Applications IHC-P
Immunogen p57/Kip2 antibody was raised using a prokaryotic recombinant antigen corresponding to a 116 amino acid region of the N-terminus of the p57 protein.

Specifications

Host Mouse
Clone 25B2
Isotype IgG1
Form & Buffer Lyophilized from liquid tissue culture supernatant containing sodium azide. Reconstitute in 1 ml distilled water.

Usage & Assay Information

Usage Recommendations 1:50 for 30 minutes at 25 deg C. The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections.

Storage & Safety

Storage Store at 4 deg C. DO NOT FREEZE. Return to 4 deg Cimmediately after use.

General Information

Product Use p57 antibody is for use in immunohistochemistry on paraffin sections
Biological Significance p57/Kip2 is also known as Cyclin-dependent kinase inhibitor 1C(CDKN1C). p57/Kip2 is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation.
Implications in Disease Mutations of the CDKN1C gene which encodes p57, are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate.

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Availability: In stock

Price: €1,091.21
Size: 1 ml
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