PAI1 antibody (HRP) (60R-1079)
Sheep polyclonal PAI1 antibody (HRP) conjugated
Overview
Overview
| Synonyms | Polyclonal PAI1 antibody, Anti-PAI1 antibody, PAI-1 antibody, PAI 1, PAI1, PAI 1 antibody, PAI-1, Serpin E1 antibody, Plasminogen Activator Inhibitor-1 antibody, PAI-1 antibody |
|---|---|
| Applications | User optimized |
| Immunogen | PAI1 antibody (HRP) was raised in sheep using Recombinant Plasminogen Activator Inhibitor-1 prepared from bacterial extracts as the immunogen. |
Specifications
| Host | Sheep |
|---|---|
| Isotype | IgG |
| Tag/Conjugate | HRP |
| Form & Buffer | Supplied in liquid form in a buffered stabilizer solution containing 50% (v/v) glycerol. |
Storage & Safety
| Storage | Store at -10 to -20 deg C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Allow product to warm to room temperature and gently mix before use. |
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General Information
| Biological Significance | PAI1 is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFa, glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases. |
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