PAK4 protein (His tag) (80R-1077)
Purified recombinant Human PAK4 protein
|Synonyms||PAK 4, Serine/threonine protein kinase PAK 4 protein, PAK-4 protein, PAK4, p21 activated kinase 4 isoform 1 protein, Serine threonine kinase PAK 4 protein, Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs protein, PAK 4 protein, Serine/threonine protein kinase PAK4., PAK 4 protein, p21 protein (Cdc42/Rac)-activated kinase 4 protein, p21-activated kinase 4 isoform 1 KIAA1142 protein, p21 activated kinase 4 protein, Serine/threonine-protein kinase protein, p21(CDKN1A) activated kinase 4 protein, PAK-4|
Coomassie Blue stained SDS-PAGE of PAK4 protein (His tag) (80R-1077)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-591 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFG KRKKRVEISA PSNFEHRVHT GFDQHEQKFT GLPRQWQSLI EESARRPKPL VDPACITSIQ PGAPKTIVRG SKGAKDGALT LLLDEFENMS VTRSNSLRRD SPPPPARARQ ENGMPEEPAT TARGGPGKAG SRGRFAGHSE AGGGSGDRRR AGPEKRPKSS REGSGGPQES SRDKRPLSGP DVGTPQPAGL ASGAKLAAGR PFNTYPRADT DHPSRGAQGE PHDVAPNGPS AGGLAIPQSS SSSSRPPTRA RGAPSPGVLG PHASEPQLAP PACTPAAPAV PGPPGPRSPQ REPQRVSHEQ FRAALQLVVD PGDPRSYLDN FIKIGEGSTG IVCIATVRSS GKLVAVKKMD LRKQQRRELL FNEVVIMRDY QHENVVEMYN SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLA VLQALSVLHA QGVIHRDIKS DSILLTHDGR VKLSDFGFCA QVSKEVPRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP RLKNLHKVSP SLKGFLDRLL VRDPAQRATA AELLKHPFLA KAGPPASIVP LMRQNRTR|
|Grade & Purity||> 90% pure|
|Molecular Weight||68.3 kDa (628 aa)|
|Form & Buffer||Supplied as a liquid in 50mM Tris-HCl, pH 8.0, containing 2 mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||PAK4 is a member of the group B family of p21-activated kinases (PAK). It's identified as an effector protein for cell division cycle 42(Cdc42) and protein that play an important role in regulating cytoskeletal organization and cell morphology. Its expression is elevated in many cancer cell lines, and it has been suggested that it plays an important role in tumorigenesis. Recombinant PAK4 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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