Monoclonal PAPPA antibody, Anti-PAPPA antibody, Pregnancy Associated Plasma Protein A antibody, PAPP-A antibody, PAPP A antibody, PAPPA antibody, PAPP A antibody, Anti PAPPA antibody, PAPP-A antibody, Pregnancy Associated Plasma Protein A antibody
Specificity
Human
Cross Reactivity
To be determined by end-user
Applications
ELISA, IP, WB
Immunogen
PAPPA antibody was raised in mouse using purified human PAPP-A/proMBP complex or purified human atherosclerotic tissue form of PAPP-A as the immunogen.
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
General Information
Biological Significance
Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome. PAPPA is a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses