PAPPA protein (30-1024)

Purified native Human PAPPA protein

Synonyms ASBABP2 protein, Pappalysin 1 protein, PAPP A protein, IGFBP4ase protein, DIPLA1 protein, PAPP-A protein, Pregnancy Associated Plasma Protein A protein
Species Human
Protein Type Native

Specifications

Source Human Placenta serum
Grade & Purity > 80% pure
Form & Buffer Supplied frozen (Aseptically Filtered through 0.2 u) in 10 mM Tris Buffer, pH: 7.4 + 0.2, 0.15M NaCl, 0.09% Azide and 0.01% NGME

Storage & Safety

Storage Ships on dry ice. Upon receipt aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information Use only in In-Vitro research or products. All bio-safety precautions must be practiced while handling.

General Information

Biological Significance Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome and more recently as a cardiac marker. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome.

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Availability: In stock

Price: €486.71
Size: 100 ug
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