Parathyroid Hormone protein (30R-1048)
Purified recombinant Human Parathyroid Hormone protein
|Synonyms||Parathormone protein, Human Parathyroid Hormone protein, Parathyroid hormone protein, hPTH protein, PTH protein, PTH protein, Parathyrin protein, Parathormone protein|
Coomassie Blue stained SDS-PAGE of Parathyroid Hormone protein (30R-1048)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ|
|Grade & Purity||> 95% pure|
|Molecular Weight||9.55 kDa (85 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in PBS, pH 7.4, containing 2mM EDTA.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Human parathyroid hormone (hPTH) is an 84 amino acid residue peptide and one of the main regulators in maintenance of calcium homeostasis. It acts primarily on kidney and bone cells stimulating calcium resorption or calcium mobilization, respectively. The whole mechanism is still under discussion, but low-dose hPTH triggers cyclic AMP-dependent protein kinase in some populations of bone cells bearing PTH receptors, which stimulates the proliferation of osteoblasts. Human parathyroid hormone(amino acids 1-84) was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques|
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