PARP1 protein (30R-1469)
Purified recombinant Human PARP1 protein
|Synonyms||PARP1 protein, Poly (ADP-ribose) polymerase family protein, NAD(+) ADP ribosyltransferase 1 protein, member 1 ADP ribosyltransferase (NAD+ protein, pADPRT-1 protein, sPARP1., PARP-1 protein, PPOL protein, Poly[ADP ribose] synthetase 1 protein, ADPRT1 protein, poly(ADP ribose) synthetase protein, Poly (ADP ribose) polymerase 1 protein, poly(ADP ribosyl)transferase protein, ADPRT 1 protein, PARP 1 protein, ADPRT protein, poly (ADP ribose) polymerase) protein, PARP 1, PARP1, sPARP 1 protein, msPARP protein, pADPRT protein, PARP protein, pADPRT 1 protein, PARP 1 protein, PARP-1, PARP-1 protein|
Coomassie Blue stained SDS-PAGE of PARP1 protein (30R-1469)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||662-1014 amino acids: MKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KAEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW|
|Grade & Purity||> 95% pure|
|Molecular Weight||39.6 kDa (354aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PARP1 is a nuclear DNA-binding zinc finger protein which can exist as a homo- or hetero-dimer, and is strongly activated by DNA strand breaks. This protein involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP1 also plays a role in other cellular processes, including cell proliferation and differentiation. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADPribosyl)ation contributes to the efficient maintenance of genome integrity. Recombinant PARP1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
Sorry, but there are no references currently for this product.
You need to be logged in to write a review. Please login here
Sorry there are currently no reviews for this product