PD1 antibody (10R-6704)

Rat monoclonal PD1 antibody

Synonyms Monoclonal PD1 antibody, Anti-PD1 antibody, PD 1, PD 1 antibody, PD-1, PD1 antibody, PD-1 antibody, PD1
Specificity Mouse
Applications Functional Assay
Assay Information The ED50 of this protein, as measured by balb/c-3T3 cell proliferation, is 0.1-1.25 ng/ml. This corresponds to a specific activity of 1 x 107- 8 x105 Units/mg.

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Specifications

Host Rat
Clone RMP1-14
Isotype IgG2a kappa
Method of Purification PD1 antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration 100 ug/ml

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance This antibody reacts with mouse PD-1, a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 and PD-L2. Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1, RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.

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Availability: In stock

Price From: Price: €134.97

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Price From: Price: €134.97
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