PDCD12 antibody (10R-1111)
Mouse monoclonal PDCD12 antibody
Overview
Overview
| Synonyms | Monoclonal PDCD12 antibody, Anti-PDCD12 antibody, PDCD-12 antibody, programmed cell death 12 antibody, cell death regulator aven antibody, PDCD12, caspase activation inhibitor antibody, PDCD 12 antibody, PDCD-12, PDCD 12, PDCD12 antibody, apoptosis antibody |
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| Specificity | Human |
| Cross Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Immunogen | PDCD12 antibody was raised in mouse using recombinant human PDCD12 (254-362aa) purified from E. coli as the immunogen. |
Images
Immunohistochemical staining using PDCD12 antibody (10R-1111)
Paraffin embedded sections of human breast lobule tissue were initrocelluloseubated with anti-human PDCD12 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB)
Specifications
| Host | Mouse |
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| Clone | 3G4 |
| Isotype | IgG2a kappa |
| Source | Anti-human PDCD12 antibody, clone 3G4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PDCD12 protein. |
| Method of Purification | PDCD12 antibody was purified by protein-G affinity chromatography |
| Form & Buffer | Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | WB: 1:500-1:1,000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | PDCD12 (Programmed cell death 12), also referred to as AVEN, represents a new class of cell death regulator. PDCD12 is a conserved intracellular membrane protein that blocks apoptosis impeded by Apaf-1 mediated caspase activation. Bcl-2 and BAD also interact with PDCD12 to prevent apoptosis. It is expressed in a wide variety of normal tissues including heart, skeletal muscle, kidney, liver, testis, and diseases such as cancer |
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