PDE6D protein (His tag) (80R-1317)
Purified recombinant Human PDE6D protein
|Synonyms||PDED-6, cGMP-specific protein, PDED protein, PDED 6 protein, delta, 5'-cyclic phosphodiesterase subunit delta protein, PDED-6 protein, rod protein, PDE6D, PDED 6, Retinal rod rhodopsin-sensitive cGMP 3' protein, phosphodiesterase 6D protein|
Coomassie Blue stained SDS-PAGE of PDE6D protein (His tag) (80R-1317)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-150 amino acids: MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV GSHHHHHH|
|Grade & Purity||> 90% pure|
|Molecular Weight||18.4 kDa (158aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT and 100mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Human PDE6D was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase, PDE6. Catalytically active PDE6 is a heterodimer (??) that is regulated by two inhibitory gamma subunits. As PDE6D does not modify the catalytic properties of PDE, its function is still unresolved. Recombinant human PDE6D, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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