PDGF Receptor beta antibody (Phospho-Tyr740) (20R-2892)
Rabbit polyclonal PDGF Receptor beta antibody (Phospho-Tyr740)
Overview
Overview
| Synonyms | Polyclonal PDGF Receptor beta antibody, Anti-PDGF Receptor beta antibody, PDGFRB antibody, platelet-derived growth factor receptor antibody, beta polypeptide antibody, beta platelet-derived growth factor receptor antibody, beta-type platelet-derived growth factor receptor antibody, BOS_8330 antibody, CD140 antigen-like family member B antibody, CD140B antibody, JTK12 antibody, PDGF beta chain antibody, Pdgfr antibody, PDGFR1 antibody, PDGFR-1 antibody, PDGFRbeta antibody, PDGF-R-beta antibody, PDGFR-beta antibody, PGF-Rb antibody, platelet-derived growth factor receptor 1 antibody, platelet-derived growth factor receptor beta antibody, Platelet-derived growth factor receptor antibody, beta antibody, platelet-derived growth factor receptor beta 2 antibody, platelet derived growth factor receptor antibody, beta polypeptide antibody, platelet-derived growth factor receptor beta variant 1 antibody, protein tyrosin kinase antibody |
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| Cross Reactivity | Human, Mouse |
| Applications | WB |
| Immunogen | PDGF Receptor beta antibody was raised in Rabbit using Synthetic phospholyrated peptide (KLH coupled) corresponding to residues surrounding Tyr 740 of human PDGF Receptor b as the immunogen |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:2000 |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | PDGFR-alpha and PDGFR-beta have five extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo- and heterodimers. Dimerization of the receptors juxtaposes the intracellular part of the receptors, which allow phosphorylation in trans between the two receptors in the complex. These autophosphorylation provide docking sites for downstream signal transduction molecules. More than 10 different SH2?domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF alpha- and beta-receptors. There are signal transduction molecules with enzymatic activity, such as PI3-kinase, PLC-gamma, Src, SHP-2, GAP, as well as adaptor molecules such as Grb2, Shc, Nck, Grb7 and Crk, and Stats. Each of the different partners recruited by the activated receptor initiates different signaling pathways, making possible a great variety of cellular response. |
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