PDK1 protein (His tag) (80R-2556)
Purified recombinant Human PDK1 protein
Overview
Overview
| Synonyms | isozyme 1 protein, Pyruvate dehydrogenase kinase protein, Pyruvate dehydrogenase kinase protein, isoenzyme 1., Mitochondrial pyruvate dehydrogenase kinase isoenzyme1 protein, PDK-1 protein, PDK 1 protein, PDK 1, isozyme 1 HGNC:8809 protein, Pyruvate dehydrogenase kinase protein, Pyruvate dehydrogenase kinase isoform 1 protein, PDK1, PDK-1, PDK1 protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Expression System | Sf-9 insect cells |
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| Method of Purification | PDK1 protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 59 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in a storage buffer consisting of 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF and 25% glycerol |
Storage & Safety
| Storage | Store at -80 deg C |
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General Information
| Biological Significance | PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) that is a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth. |
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