Perlecan antibody (10R-P118a)

Rat monoclonal Perlecan antibody

Synonyms Monoclonal Perlecan antibody, Anti-Perlecan antibody
Specificity Murine
Cross Reactivity Cow, human, pig
Applications IF, IHC-F, IHC-P, WB
Immunogen Perlecan antibody (biotin) was raised in rat using murine EHS laminin preparation as the immunogen.

Images

Immunohistochemical staining using Perlecan antibody (10R-P118a)

Frozen human tonsil stained with Perlecan antibody using peroxidase-conjugate and DAB chromogen. Note basement membrane and cell surface staining of blood vessels.

Specifications

Host Rat
Clone A7L6
Isotype IgG2a kappa
Method of Purification Perlecan antibody was purified by Protein G chromatography.
Form & Buffer 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.
Concentration 0.2 mg/ml

Usage & Assay Information

Usage Recommendations IHC-F: 1-2 ug/ml, IHC-P: 1-2 ug/ml WB: 1-2 ug/ml

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growthpromoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

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Images

  • Immunohistochemical staining using Perlecan antibody (10R-P118a) | Frozen human tonsil stained with Perlecan antibody using peroxidase-conjugate and DAB chromogen. Note basement membrane and cell surface staining of blood vessels.

Availability: In stock

Price: €455.37
Size: 100 ug
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