pH2AX antibody (20R-2887)
Rabbit polyclonal pH2AX antibody
Overview
Overview
| Synonyms | Polyclonal pH2AX antibody, Anti-pH2AX antibody, H2AFX antibody, H2A histone family antibody, member X antibody, BOS_14476 antibody, EGK_06977 antibody, gammaH2ax antibody, H2AFJ antibody, H2A histone family antibody, member J antibody, h2ax antibody, H2A/X antibody, H2A.X antibody, H2AX histone antibody, hist1h2ab antibody, Hist5-2ax antibody, histone 1 antibody, H2ab antibody, histone 5 protein 2ax antibody, histone H2A type 1 antibody, histone H2A.x antibody, RGD1566119 antibody |
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| Cross Reactivity | Human |
| Applications | WB |
| Immunogen | pH2AX antibody was raised in Rabbit using a synthetic target peptide as the immunogen |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | pH2AX antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:5000 |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | H2AX becomes phosphorylated on serine 139, then called gamma-H2AX, as a reaction on DNA Double-strand breaks (DSB). The kinases of the PI3-family (Ataxia telangiectasia mutated, ATR and DNA-PKcs) are responsible for this phosphorylation, especially ATM. The modification can happen accidentally during replication fork collapse or in the response to ionizing radiation but also during controlled physiological processes such as V(D)J recombination. |
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