PHF11 protein (His tag) (80R-2568)
Purified recombinant PHF11 protein
Overview
Overview
| Synonyms | PHF-11, RP11-185C18.3 protein, APY protein, IGER protein, BCAP protein, IGHER protein, IGEL protein, PHF 11, PHF11, NY-REN-34 protein, NYREN34 protein, PHD finger protein 11 protein, PHF 11 protein, PHF-11 protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS-PAGE analysis of PHF11 protein (His tag) (80R-2568)
SDS-PAGE gel analysis of PHF11 protein (His tag) where the figure is annotated with amount of protein run on the gel.
Specifications
| Residues | 1-331 aa: MGSSHHHHHH SSGLVPRGSH MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK DVEYNVLYFA QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK EIQRGRKLKC KFCHKRGATV GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR KKPLSGNHVQ PPETMKCNTF IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK VHSIPEKLMD ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y |
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| Expression System | E.coli |
| Grade & Purity | > 85% pure |
| Molecular Weight | 39.7 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage, for long term storage aliquot and freeze at -20 deg C or -70 deg C |
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General Information
| Biological Significance | PHD finger protein 11, also known as PHF11, is a regulator of TH1-type cytokine gene expression. The reduction in PHF11 expression seen with an AD-associated genotype could contribute to the strong TH2 responses that characterize many allergic individuals. PHF11 are associated with increased total serum IgE levels, asthma, and severe atopic dermatitis (AD) in children. Although PHF11 includes a plant homeodomain, a motif often found in transcriptional regulators, the function of PHF11 has not been investigated. |
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