Phospho-STAT3 antibody (70R-11852)

Rabbit polyclonal Phospho-STAT3 antibody

Synonyms Polyclonal Phospho-STAT3 antibody, anti-Phospho-STAT3 antibody, MGC60396 antibody, HSPC193 antibody, MADH3 antibody, Mad3 antibody, JV15-2 antibody, Phospho-STAT 3 antibody, DKFZp686J10186 antibody, hSMAD3 antibody, Phospho-STAT3, DKFZP586N0721 antibody, Phospho-STAT 3, hMAD-3 antibody, Phospho-STAT-3, Phospho-STAT-3 antibody, HsT17436 antibody
Cross Reactivity Human, Mouse
Applications IHC, IP, WB
Immunogen Phospho-STAT3 antibody was raised in Rabbit using synthetic phospho-peptide corresponding to resides surrounding Ser727 of mouse Stat3 as the immunogen.

Specifications

Host Rabbit
Isotype IgG
Method of Purification Phospho-STAT3 antibody was purified by affinity chromatography
Form & Buffer Supplied in PBS buffer containing 50% glycerol, 1% BSA, and 0.02% thimerosal
Concentration 500 ug/ml

Usage & Assay Information

Usage Recommendations IP: 20 mg/ml, IHC: 20 ug/ml, WB: 1-4 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3beta appears to be activated by both while Stat3alpha is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: €347.65
Size: 100 ug
OR
Shipping
View Our Distributors