Phospho-STAT3 antibody (70R-11852)
Rabbit polyclonal Phospho-STAT3 antibody
Overview
Overview
| Synonyms | Polyclonal Phospho-STAT3 antibody, anti-Phospho-STAT3 antibody, MGC60396 antibody, HSPC193 antibody, MADH3 antibody, Mad3 antibody, JV15-2 antibody, Phospho-STAT 3 antibody, DKFZp686J10186 antibody, hSMAD3 antibody, Phospho-STAT3, DKFZP586N0721 antibody, Phospho-STAT 3, hMAD-3 antibody, Phospho-STAT-3, Phospho-STAT-3 antibody, HsT17436 antibody |
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| Cross Reactivity | Human, Mouse |
| Applications | IHC, IP, WB |
| Immunogen | Phospho-STAT3 antibody was raised in Rabbit using synthetic phospho-peptide corresponding to resides surrounding Ser727 of mouse Stat3 as the immunogen. |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Phospho-STAT3 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in PBS buffer containing 50% glycerol, 1% BSA, and 0.02% thimerosal |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Usage Recommendations | IP: 20 mg/ml, IHC: 20 ug/ml, WB: 1-4 ug/ml |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3beta appears to be activated by both while Stat3alpha is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. |
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