PIM1 antibody (70R-12089)
Rabbit polyclonal PIM1 antibody
Overview
Overview
| Synonyms | Polyclonal PIM1 antibody, anti-PIM1 antibody, PIM1 antibody, PIM antibody, PIM-1 antibody, PIM-1 antibody, Proviral Integration Site 1 antibody, PIM-1, PIM 1 antibody, PIM1, PIM 1 |
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| Cross Reactivity | Human, Mouse, Rat |
| Applications | IP, WB |
| Immunogen | PIM1 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 296 of rat PIM1 as the immunogen. |
| Assay Information | PIM1 Blocking Peptide, catalog no. 33R-10916, is also available for use as a blocking control in assays to test for specificity of this PIM1 antibody |
Images
Western Blot analysis using PIM1 antibody (70R-12089)
Western blot analysis of PIM1 using Jurkat cell lysate.
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | PIM1 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal |
| Concentration | 500 ug/ml |
Usage & Assay Information
| Usage Recommendations | WB: 0.5-4 ug/ml |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | The proto-oncogene Pim1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Pim1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others. Expression of Pim1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Recently, Pim1 has been shown to enhance the activities of p100, c-Myb and Cdc 25a and in part this might explain reported effects of Pim1 on mitogenesis. |
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