PKC gamma protein (30R-2876)
Purified recombinant Human PKC gamma protein
Overview
Overview
| Synonyms | PKC protein, protein kinase C protein, gamma kinase C protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Expression System | Sf-9 insect cells |
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| Grade & Purity | > 80% pure |
| Method of Purification | PKC gamma protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 105 kDa |
| Form & Buffer | Supplied in a storage buffer consisting of 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF and 25% glycerol |
Usage & Assay Information
| Bioactivity | The specific activity of PKC gammais approximately 512 nmol/min/mg |
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Storage & Safety
| Storage | Store at -80 deg C |
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General Information
| Biological Significance | PKC gamma is a member of the protein kinase C family of serine-and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. In the brain, PKC is translocated to cell membranes during ischemia and is rapidly removed or degraded during the second otherwise lethal ischemic insult in preconditioned brains. This suggest that ischemic preconditioning enhances downregulation of cell signaling mediated by PKC and may thereby provide neuroprotection. |
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