Polyclonal PKC zeta antibody, Anti-PKC zeta antibody, EC 2.7.11.13 antibody, KPCZ antibody, PKC-zeta antibody, PKC2 antibody, PRKCZ antibody, Protein kinase C zeta type antibody, kinase PKC-zeta antibody, nPKC-zeta antibody
Specificity
PKC zeta antibody detects endogenous levels of total PKC zeta protein
Cross Reactivity
Mouse, Rat
Applications
ELISA, IF, IHC, WB
Immunogen
PKC zeta antibody was raised in Rabbit using a synthesized non-phospho derived from human PKC zeta around the phosphorylation site of threonine 410 (T-S-TF-C) as the immunogen
Store at -20 deg C in small aliquots. Avoid repeated freeze-thaw cycles
General Information
Biological Significance
PKC-zeta has an N-terminal regulatory domain, followed by a hinge region and a C-terminal catalytic domain. Second messengers stimulate PKCs by binding to the regulatory domain, translocating the enzyme from cytosol to membrane, and producing a conformational change that removes auto-inhibition of the PKC catalytic protein kinase activity.