Platelet glycoprotein IIb/IIIa antibody (70R-10576)
Affinity purified sheep polyclonal Platelet glycoprotein IIb/IIIa antibody
Overview
Overview
| Synonyms | Polyclonal Platelet glycoprotein IIb/IIIa antibody, Anti-Platelet glycoprotein IIb/IIIa antibody, gpIIb/IIIa antibody |
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| Applications | User optimized |
| Immunogen | Platelet glycoprotein IIb/IIIa antibody was raised in sheep using purified glycoprotein IIb/IIIa complex (GPIIb/IIIa) prepared from platelets as the immunogen. |
Specifications
| Host | Sheep |
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| Isotype | IgG |
| Method of Purification | Platelet glycoprotein IIb/IIIa antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in liquid form in a buffered stabilizer solution containing 50% (v/v) glycerol. |
Storage & Safety
| Storage | Store at -10 to -20 deg C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Allow product to warm to room temperature and gently mix before use. |
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General Information
| Biological Significance | Glycoprotein IIb/IIIa (gpIIb/IIIa, also known as integrin alpha-IIb, beta-3) is an integrin complex found on platelets. It is a receptor for fibrinogen and aids in platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence. Platelet activation by ADP (blocked by clopidogrel) leads to a conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrinogen. The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban. |
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