PLP1 antibody (70R-10646)
Affinity purified Chicken polyclonal PLP1 antibody
Overview
Overview
| Synonyms | Polyclonal PLP1 antibody, Anti-PLP1 antibody, PLP antibody, SPG2 antibody, PLP-1, PLP1, MMPL antibody, PLP/DM20 antibody, Proteolipid Protein 1 antibody, PLP-1 antibody, PMD antibody, PLP 1 antibody, PLP 1 |
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| Applications | ICC, IHC, WB |
| Immunogen | PLP1 antibody was raised in Chicken using a synthetic peptide / keyhole limpet hemocyanin (KLH) conjugate corresponding to a region of the PLP gene product shared between the Human (NP_000524, PLP1 isoform 1 and PLP1 isoform 2 (NP_955772)] and Mouse (P6 |
Images
Immunofluorescent staining of PLP1 antibody (70R-10646)
In this tissue section through an e13 mouse brain, PLP (green staining) can be seen in immature oligodendrocytes of white matter tracts. DAPI (blue staining) allows visualization of nuclei.
Specifications
| Host | Chicken |
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| Method of Purification | PLP1 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in liquid form in 10 mM PBS buffer, pH 7.2, with 0.02% sodium azide added as a preservative. |
| Concentration | 100 ug/ml |
Usage & Assay Information
| Usage Recommendations | ICC: 1:1000-1:2000; IHC: 1:1000-1:2000; WB: 1:2000-1:5000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. Protect from light. |
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General Information
| Biological Significance | PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. |
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