PPP3R1 protein (His tag) (80R-1659)
Purified recombinant Human PPP3R1 protein
|Synonyms||CNB1, PPPR1-3, PPPR1-3 protein, PPPR1 3, CNB protein, Calcineurin subunit B type 1 protein, Protein phosphatase 3 regulatory subunit B alpha protein, PPP3R1, CALNB1 protein, PPPR1 3 protein|
Coomassie Blue stained SDS-PAGE of PPP3R1 protein (His tag) (80R-1659)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-170 amino acids: MGSSHHHHHH SSGLVPRGSH MGNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV|
|Grade & Purity||> 90% pure|
|Molecular Weight||21.5 kDa (190aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 2mM DTT and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. Recombinant human PPP3R1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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