Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
The presenilin-1 (PS-1) gene was found on chromosome 14 and is responsible for an early onset form of Alzheimer's disease (AD) that accounts for 70-80% of the inherited forms of Alzheimer's. It is a membrane protein that has a region where at least seven mutations have been identified in family members with AD. The gene sequence of PS-1 does not match any known human gene sequences with the exception of PS-2; but has been found to be a new class of aspartic–proteases. It has now been identified as one of the g-secretase proteases.