Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
The presenilin-2 (PS-2) gene was discovered on chromosome 1 and is responsible for an early onset form of autosomal dominant Alzheimer's disease (AD). The amino acid sequence is approximately 67% identical with that of the PS-1 protein. It also is a membrane protein that has regions where mutations have been identified in family members with AD. The gene sequence of PS-2 does not match any known human gene sequences, except for that of PS-1; but has been found to be a new class of aspartic-proteases. It has now been identified as one of the secretase proteases.