Presenilin 2 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human Presenilin-2, different from the related Rabbit and rat sequences by two amino acids, as the immunogen
Immunohistochemical staining using Presenilin 2 antibody (70R-13901)
Immunohistochemistry of paraffin embedded section of Human Mammary Cancer Tissue
Presenilin 2 antibody
Immunohistochemical staining using Presenilin 2 antibody (70R-13901)
Immunohistochemistry of paraffin embedded section of Human Mammary Cancer Tissue
Western blot analysis using Presenilin 2 antibody (70R-13901)
Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Brain Tissue Lysate, Lane 3: MCF-7 Cell Lysate, Lane 4: HELA Cell Lysate, ,Lane 5: SMMC Cell Lysate, Lane 6: CEM Cell Lysate
Specifications
Host
Rabbit
Isotype
IgG
Method of Purification
Presenilin 2 antibody was purified by affinity chromatography
Optimal conditions to be determined by the end user
Storage & Safety
Storage
Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.
General Information
Biological Significance
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP.