PRKAB1 protein (His tag) (80R-2564)
Purified recombinant PRKAB1 protein
Overview
Overview
| Synonyms | PRKAB-1, PRKAB 1 protein, 5'-AMP-activated protein kinase subunit beta-1 protein, PRKAB1, HAMPKb protein, PRKAB 1, AMPK protein, PRKAB-1 protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS-PAGE analysis of PRKAB1 protein (His tag) (80R-2564)
SDS-PAGE gel analysis of PRKAB1 protein (His tag) where the figure is annotated with amount of protein run on the gel.
Specifications
| Residues | 1-270 aa: MGSSHHHHHH SSGLVPRGSH MGSMGNTSSE RAALERHGGH KTPRRDSSGG TKDGDRPKIL MDSPEDADLF HSEEIKAPEK EEFLAWQHDL EVNDKAPAQA RPTVFRWTGG GKEVYLSGSF NNWSKLPLTR SHNNFVAILD LPEGEHQYKF FVDGQWTHDP SEPIVTSQLG TVNNIIQVKK TDFEVFDALM VDSQKCSDVS ELSSSPPGPY HQEPYVCKPE ERFRAPPILP PHLLQVILNK DTGISCDPAL LPEPNHVMLN HLYALSIKDG VMVLSATHRY KKKYVTTLLY KPI |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 85% pure |
| Molecular Weight | 32.8 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
| Concentration | 0.5 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage, for long term storage aliquot and freeze at -20 deg C or -70 deg C |
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General Information
| Biological Significance | PRKAB1 inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
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