PRL3 protein (His tag) (80R-1203)
Purified recombinant Human PRL3 protein
|Synonyms||PTP 4A3 protein, Protein tyrosine phosphatase type IVA 3 Potentially prenylated protein tyrosine phosphatase protein, PRL3 protein, PRL R protein, PRL 3 protein, Protein Tyrosine Phosphatase Type IVA Member 3, PRL-3, PTP4A3 protein, PRL3, PRLR protein, PRL 3, PRL 3 protein, Protein tyrosine phosphatase 4a3 protein, PRL-3 protein|
Coomassie Blue stained SDS-PAGE of PRL3 protein (His tag) (80R-1203)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-173 amino acids: MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM|
|Grade & Purity||> 95% pure|
|Molecular Weight||21.6 kDa (193aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM EDTA, 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method )|
|Biological Significance||Protein tyrosine phosphatase type IVA 3 (PRL-3), as known as PTP4A3, belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) that remove phosphate modifications from tyrosine residues on proteins. This protein enhances cell proliferation, cell motility and invasive activity. High levels of PRL-3 expression are associated with tumorigenesis and metastasis, thus it is overexpressed in metastatic colorectal, ovarian, liver and skin cancers. Recombinant human PRL-3, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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