PRMT1 protein (30R-2391)
Purified recombinant Mouse PRMT1 protein
Overview
Overview
| Synonyms | PRMT-1 protein, PRMT 1, Protein arginine N-methyltransferase 1 (EC 211-) (Histone-arginine N-methyltransferase PRMT1) (EC 211125) protein, PRMT-1, PRMT 1 protein, PRMT1 |
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| Species | Mouse |
| Protein Type | Recombinant |
Specifications
| Expression System | E.coli |
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| Grade & Purity | > 90% pure |
| Method of Purification | PRMT1 protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 84.0 kDa |
| Form & Buffer | Supplied in liquid form in 40mM Tris-HCl pH 8.0, 100mM NaCl, 4mM MgCl2, 2mM DTT & 40% glycerol |
Storage & Safety
| Storage | Store at -80 deg C |
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General Information
| Biological Significance | PRMT1 methylate’s the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain methylate’s SUPT5H. The PRMT1 protein functions as a histone methyltransferase specific for H4. PRMT1 is an essential factor in oncogenesis and is a potential novel therapeutic target in cancer. PRMT1-mediated methylation serves as a positive modulator of IR/IRS-1/PI3K pathway and glucose uptake in skeletal muscle cells. CAF1 is a new regulator of PRMT1-dependent arginine methylation. PRMT1 arginine-methylate’s MRE11 therefore it regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response. |
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