PRMT1 protein (30R-2391)

Purified recombinant Mouse PRMT1 protein

Synonyms PRMT-1 protein, PRMT 1, Protein arginine N-methyltransferase 1 (EC 211-) (Histone-arginine N-methyltransferase PRMT1) (EC 211125) protein, PRMT-1, PRMT 1 protein, PRMT1
Species Mouse
Protein Type Recombinant

Specifications

Expression System E.coli
Grade & Purity > 90% pure
Method of Purification PRMT1 protein was purified using a a proprietary chromatographic technique.
Molecular Weight 84.0 kDa
Form & Buffer Supplied in liquid form in 40mM Tris-HCl pH 8.0, 100mM NaCl, 4mM MgCl2, 2mM DTT & 40% glycerol

Storage & Safety

Storage Store at -80 deg C

General Information

Biological Significance PRMT1 methylate’s the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain methylate’s SUPT5H. The PRMT1 protein functions as a histone methyltransferase specific for H4. PRMT1 is an essential factor in oncogenesis and is a potential novel therapeutic target in cancer. PRMT1-mediated methylation serves as a positive modulator of IR/IRS-1/PI3K pathway and glucose uptake in skeletal muscle cells. CAF1 is a new regulator of PRMT1-dependent arginine methylation. PRMT1 arginine-methylate’s MRE11 therefore it regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.

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