PRNP protein (His tag) (80R-2717)
Purified recombinant PRNP protein (His tag)
|Synonyms||Prion protein preproprotein protein, ASCR protein, CD230 protein, CJD protein, GSS protein, MGC26679 protein, prion protein, PRIP protein, PrP protein, PrP27-30 protein, PrP33-35C protein, PrPc protein, PRNP|
SDS-PAGE analysis of PRNP protein (His tag) (80R-2717)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||23-230 aa: MGSSHHHHHH SSGLVPRGSH MKKRPKPGGW NTGGSRYPGQ GSPGGNRYPP QGGGGWGQPH GGGWGQPHGG GWGQPHGGGW GQPHGGGWGQ GGGTHSQWNK PSKPKTNMKH MAGAAAAGAV VGGLGGYVLG SAMSRPIIHF GSDYEDRYYR ENMHRYPNQV YYRPMDEYSN QNNFVHDCVN ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCITQYERE SQAYYQRGS|
|Grade & Purity||> 90% pure|
|Molecular Weight||25 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 1M Urea, 10% glycerol|
Storage & Safety
|Storage||Can be stored at 4 deg C for short terms (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles|
|Biological Significance||Prion protein, also known as PRNP, is a ubiquitous membrane glycoprotein whose abnormal self-replicating, misfolded form is widely believed to cause several central nervous system disorders, collectively known as Transmissible Spongiform Encephalopathies (TSE). This protein contains a highly unstable region of five tandem octapeptide repeat. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Recombinant human PRNP protein, fused to His-tag at N-terminus, was expressed in E.coli.|
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